By Samir Shaheen-Hussain
The “thrifty gene” has a decades-long history that can be traced back to James V. Neel, an American physician-scientist, considered by many in his field as the “father of modern human genetics” [90]. Neel expounded his hypothesis in 1962 by proposing that such a gene would have emerged in hunter-gatherer societies as an adaptive response to a feast-and-famine lifestyle [2], but that it would have detrimental effects if food scarcity was eliminated. His idea was based on the assumption that “Indigenous bodies were genetically predisposed to diabetes, obesity, and other metabolic syndromes because of the foodways of their ancestors” [1-2], and relied on the now widely discredited “myth of forager food insecurity” [14-15, 146]. Neel’s own quest to discover the thrifty gene led him to conduct questionable studies on Indigenous populations in Brazil and Venezuela throughout the 1960s [2, 86-97]. In 1989, Neel sought to bury his own idea, writing that “the data on which that (rather soft) hypothesis was based has now largely collapsed” [100].
Yet, in 1999, Canadian scientists working with the Sandy Lake First Nation to address increasing rates of diabetes-related complications in the northern Ontario community announced to great fanfare that they had identified a genetic variant that “certainly had all the earmarks of what a thrifty gene would be” [136, 141]. Critics, including Indigenous scholars [144-5], questioned the layers of flawed premises upon which their conclusions rested and highlighted how they diverted attention away from the impacts of decades of colonial policies on Indigenous food sovereignty and mobility. Several years later, the lead authors of the study backtracked on their findings: there was no thrifty gene to be found [145-6].
This is the history that Travis Hay compellingly develops in Inventing the Thrifty Gene: The Science of Settler Colonialism. The persistence of the thrifty gene hypothesis to this day is itself reflective of the enduring consequences of the science of settler colonialism [19, 137, 149, 152].
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